Dichloromethane → Trifluoroacetic acid

HRID 1920567ノート

反応式

HRID 1920567 の反応式
F[P-](F)(F)(F)(F)F.C(OC([N:15]1[CH2:18][CH:17]([C:19]([NH:21][CH2:22][CH2:23][N+:24]23[CH2:31][CH2:30][CH:27]([CH2:28][CH2:29]2)[C@@H:26]([O:32][C:33](=[O:48])[C:34]([OH:47])([C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=2)[C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[CH2:25]3)=[O:20])[CH2:16]1)=O)(C)(C)C.[C:49]([OH:55])([C:51]([F:54])([F:53])[F:52])=[O:50].C(Cl)Cl>C(O)(C(F)(F)F)=O.C(Cl)Cl>[F:52][C:51]([F:54])([F:53])[C:49]([OH:55])=[O:50].[F:52][C:51]([F:54])([F:53])[C:49]([O-:55])=[O:50].[NH:15]1[CH2:18][CH:17]([C:19]([NH:21][CH2:22][CH2:23][N+:24]23[CH2:31][CH2:30][CH:27]([CH2:28][CH2:29]2)[C@@H:26]([O:32][C:33](=[O:48])[C:34]([OH:47])([C:41]2[CH:42]=[CH:43][CH:44]=[CH:45][CH:46]=2)[C:35]2[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=2)[CH2:25]3)=[O:20])[CH2:16]1

参加物

6

反応物 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 86639173HCID 86639173、化合物

生成物 2

HCID 6422Trifluoroacetic acidHCID 67495520HCID 67495520、化合物

試薬・触媒・溶媒 1

HCID 21863450Trifluoroacetic acid methylene chloride溶媒

実験手順

(R)-1-(2-[(1-tert-butoxycarbonyl-azetidine-3-carbonyl)-amino]ethyl]-3-(2-hydroxy-2,2-diphenyl-acetoxy)1-azonia-bicyclo[2.2.2]octane hexafluorophosphate is dissolved in TFA:DCM (1:1) (2 ml) and stirred at room temperature for 1 hour. TFA:DCM (2 ml) is added to the reaction mixture to complete the reaction. The solvent is removed in vacuo and purification of the crude residue by mass directed preparative HPLC eluting with water:acetonitrile:trifluoroacetic acid yields the titled compound.

後処理

  1. customthe reaction
  2. customThe solvent is removed in vacuo and purification of the crude residue by mass
  3. washeluting with water

出典と根拠

ORDレコード
ord-fa1bc6ae09124f3780cfef0c34443ee0
出典データセット
uspto-grants-2012_05
特許番号
US08168654B2

反応ノート

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