Ethyl 4-[(2-nitrophenyl)amino]benzoate → Ethyl 4-[(2-aminophenyl)amino]benzoate

HRID 1921197ノート

反応式

HRID 1921197 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][C:11]1[CH:21]=[CH:20][C:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:13][CH:12]=1)([O-])=O>CCO.[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][C:11]1[CH:21]=[CH:20][C:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:13][CH:12]=1

参加物

4

反応物 1

HCID 11208411Ethyl 4-[(2-nitrophenyl)amino]benzoate

生成物 1

HCID 18449398Ethyl 4-[(2-aminophenyl)amino]benzoate

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A mixture of ethyl 4-[(2-nitrophenyl)amino]benzoate from Step A (755 mg, 2.64 mmol) and 10% Pd/C (505 mg) in EtOH (25 mL) was stirred under an atmosphere of hydrogen (ca.1 atm) for 4 h. The mixture was filtered through a pad of Celite, washing with EtOH, and the filtrate was concentrated to give the title compound. MS: m/z=257 (M+1).

後処理

  1. filtrationThe mixture was filtered through a pad of Celite
  2. washwashing with EtOH
  3. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-b159f1925a5943e69478c1325bba95e5
出典データセット
uspto-grants-2012_05
特許番号
US08173655B2

反応ノート

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