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1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-(4-methyl-3-nitrophenyl)urea → 1-(3-amino-4-methylphenyl)-3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]urea

HRID 1921289
ノート
印刷プレビュー

反応式

HRID 1921289 の反応式
[C:1]([C:5]1[CH:9]=[C:8]([NH:10][C:11]([NH:13][C:14]2[CH:19]=[CH:18][C:17]([CH3:20])=[C:16]([N+:21]([O-])=O)[CH:15]=2)=[O:12])[N:7]([C:24]2[CH:29]=[CH:28][C:27]([CH3:30])=[CH:26][CH:25]=2)[N:6]=1)([CH3:4])([CH3:3])[CH3:2].[H][H]>CO.[Pd]>[NH2:21][C:16]1[CH:15]=[C:14]([NH:13][C:11]([NH:10][C:8]2[N:7]([C:24]3[CH:25]=[CH:26][C:27]([CH3:30])=[CH:28][CH:29]=3)[N:6]=[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[CH:9]=2)=[O:12])[CH:19]=[CH:18][C:17]=1[CH3:20]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 2

HCID 670568701-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-(4-methyl-3-nitrophenyl)ureaHCID 178418361HCID 178418361、化合物

生成物 1

HCID 670568481-(3-amino-4-methylphenyl)-3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]urea収率 85.9%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

1-[3-tert-Butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-(4-methyl-3-nitrophenyl)urea (93 mg) was hydrogenated over 10% Pd/C (50% wet, 10 mg) at atmospheric pressure of hydrogen in MeOH (2 mL) for 4 hr. The catalyst was removed by filtration through Celite® pad and the filtrate was evaporated in vacuo. The residue was triturated with IPE and the precipitates produced were collected by filtration to give 1-(3-amino-4-methylphenyl)-3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]urea (74 mg).

後処理

  1. customThe catalyst was removed by filtration through Celite® pad
  2. customthe filtrate was evaporated in vacuo
  3. customThe residue was triturated with IPE
  4. customthe precipitates produced
  5. filtrationwere collected by filtration

出典と根拠

ORDレコード
ord-276b6771b8f648a3b5ef5a95942ba16e
出典データセット
uspto-grants-2012_05
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08173684B2

反応ノート

読み込み中…

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