Sodium Hydroxide → HCID 57654546、化合物
反応式
[OH-].[Na+].C([O:5][C:6](=[O:23])[CH:7]([C:13]1[CH:14]=[C:15]2[C:20](=[CH:21][CH:22]=1)[N:19]=[CH:18][N:17]=[CH:16]2)C(OCC)=O)C>CO>[N:19]1[C:20]2[C:15](=[CH:14][C:13]([CH2:7][C:6]([OH:23])=[O:5])=[CH:22][CH:21]=2)[CH:16]=[N:17][CH:18]=1参加物
4
実験手順
Sodium hydroxide [2M] (0.77 mL) was added to a solution of 2-quinazolin-6-yl-malonic acid diethyl ester (0.20 g, 0.77 mmol) in methanol (10 mL) and stirred at room temperature for several hours. The reaction was evaporated, ethyl acetate was added and then 1N HCl was added dropwise until the compound went into the organic layer. The organic layer was evaporated to give 0.123 g (85%) of quinazolin-6-yl-acetic acid. 1H NMR (400 MHz, DMSO-d6) δ 9.56 (s, 1H), 9.26 (s, 1H), 7.95 (m, 3H), 3.85 (s, 2H).
後処理
- customThe reaction was evaporated
- additionethyl acetate was added
- addition1N HCl was added dropwise until the compound
- customThe organic layer was evaporated
出典と根拠
- ORDレコード
- ord-f02eee87c62b49b1bb788266ff672fdf
- 出典データセット
- uspto-grants-2012_05
- 特許番号
- US08173654B2
反応ノート
読み込み中…