関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Ethylamine | HCID 6341 | — |
| 反応物 | 4-Bromo-1-chloroisoquinoline | HCID 459766 | — |
| 生成物 | 4-bromo-N-ethylisoquinolin-1-amine | HCID 59605203 | 88% |
反応手順
To a suspension of 4-bromo-1 chloroisoquinoline (0.831 g, 3.43 mmol) in MeOH (10.3 mL, 254 mmol) was added ethylamine (70% in water, 1.1 mL). The mixture was heated at 50° C. for 16 h. The mixture was concentrated. The residue was partitioned between water (20 mL) and DCM (20 mL). DCM layer was separated. The aqueous layer was extracted with DCM (10 mL) The combined DCM solutions were dried (Na2SO4). Filtration and concentration gave 4-bromo-N-ethylisoquinolin-1-amine (0.761 g, 88%). LCMS: M+H+=251.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08173650B2 |
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| 出典データセット | uspto-grants-2012_05 |
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| ORD ID | ord-ac312d68479d428696847172550e0583 |
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| 出典メモ | uspto-grants-2012_05 |
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