2-Methylbenzimidazole → 5-((9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-6-morpholino-9H-purin-8-yl)methyl)-2-oxa-5-azabicyclo[2.2.1]heptane

HRID 1923105

反応式

HRID 1923105 の反応式
[CH3:1][C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.Cl[C:12]1[N:20]=[C:19]2[C:15]([N:16]=[C:17]([CH2:22][N:23]3[CH2:28][CH:27]4[CH2:29][CH:24]3[CH2:25][O:26]4)[N:18]2[CH3:21])=[C:14]([N:30]2[CH2:35][CH2:34][O:33][CH2:32][CH2:31]2)[N:13]=1>>[CH3:21][N:18]1[C:17]([CH2:22][N:23]2[CH2:28][CH:27]3[CH2:29][CH:24]2[CH2:25][O:26]3)=[N:16][C:15]2[C:19]1=[N:20][C:12]([N:3]1[C:4]3[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=3[N:6]=[C:2]1[CH3:1])=[N:13][C:14]=2[N:30]1[CH2:35][CH2:34][O:33][CH2:32][CH2:31]1

参加物

3

反応物 2

HCID 119842-MethylbenzimidazoleHCID 866482622-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)-5-oxa-2-aza-bicyclo[2.2.1]heptane

生成物 1

HCID 596053245-((9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-6-morpholino-9H-purin-8-yl)methyl)-2-oxa-5-azabicyclo[2.2.1]heptane

実験手順

Following General Procedure I for Buchwald coupling, 2-methylbenzimidazole and 2-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)-5-oxa-2-aza-bicyclo[2.2.1]heptane were reacted to give 384. LCMS m/z: 461.2 (MH+)

後処理

  1. customwere reacted

出典と根拠

ORDレコード
ord-80634d5c09c34dc5b32e3e3876d3a713
出典データセット
uspto-grants-2012_05
特許番号
US08173650B2

関連ノート

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