関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Propane sultone | HCID 14264 | — |
| 反応物 | 1,2,3,4-Tetrahydroquinolin-5-ol | HCID 3046036 | — |
| 溶媒 | Butyronitrile | HCID 8008 | — |
| 生成物 | 3-(5-Hydroxy-3,4-dihydro-2h-quinoline-1-yl)propanesulfonic acid | HCID 59141708 | — |
反応手順
A mixture of 0.8 g (5.36 mmol) of 5-hydroxy-1,2,3,4-tetrahydroquinoline and 0.5 g 1,3-propanesultone (4.1 mmol) in 12 ml of butyronitrile was heated at 125° C. for hours. The mixture was suction filtered and the filtrate evaporated under reduced pressure. The resulting off white compound crystallized. Product washed with ethyl ether and filtered of. Yield 0.8 g (80%)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08178360B2 |
|---|
| 出典データセット | uspto-grants-2012_05 |
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| ORD ID | ord-4f75fb939d874ca8b65e784e6f4dfb10 |
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| 出典メモ | uspto-grants-2012_05 |
|---|
