Isopropanol → 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[[2-(1H-tetrazol-1-yl)acetyl]amino]-, sodium salt, hydrate (1:1:5), (6R,7R)-

To a reactor equipped with a jacket were added 5 ml isopropanol, 5 ml water, 10 g cefazolin acid and 1.2 g sodium carbonate, stirred and heated to 50° C. until the solution was clear, the finishing point pH was adjusted to be 6.5, the mixture was directly filtered into a glass crystallizer, agitated, cooled to about 33° C., added serine, turbidness occurred in the solution, hold for 1.0 hours, added anhydrous ethanol in an amount of 15 times as much as the mixture at 2 MPa, cooled to 5-15° C. and hold at the temperature for 1 hour. The resultant was filtered, the filter cake was washed with ethanol, dried at 5° C. for 8 hours to give cefazolin sodium pentahydrate.

1. customTo a reactor equipped with a jacket
2. filtrationthe mixture was directly filtered into a glass crystallizer
3. stirringagitated
4. temperaturecooled to about 33° C.
5. additionadded serine, turbidness
6. additionadded anhydrous ethanol in an amount of 15 times as much as the mixture at 2 MPa
7. temperaturecooled to 5-15° C.
8. waithold at the temperature for 1 hour
9. filtrationThe resultant was filtered
10. washthe filter cake was washed with ethanol
11. customdried at 5° C. for 8 hours

ORDレコード

ord-499a7ed03dae4794aa088476ceaef2ab

出典データセット

uspto-grants-2012_05

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08178521B2