Benzyl 3-((tert-butoxycarbonyl)amino)-3-methylpiperidine-1-carboxylate → Tert-butyl (3-methylpiperidin-3-yl)carbamate
反応式
[C:1]([O:5][C:6]([NH:8][C:9]1([CH3:25])[CH2:14][CH2:13][CH2:12][N:11](C(OCC2C=CC=CC=2)=O)[CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[CH3:25][C:9]1([NH:8][C:6](=[O:7])[O:5][C:1]([CH3:4])([CH3:3])[CH3:2])[CH2:14][CH2:13][CH2:12][NH:11][CH2:10]1参加物
4
実験手順
Benzyl 3-(tert-butoxycarbonylamino)-3-methylpiperidine-1-carboxylate (1.4 g, 4.0 mmol) and 10% Pd/C (0.21 g, 0.2 mmol) in MeOH (20 mL) were stirred under H2 atmosphere (1 atm) for 1 hour. The catalyst was removed by filtration and washed with methanol. The filtrate was concentrated to give tert-butyl 3-methylpiperidin-3-ylcarbamate (0.62 g, 72% yield) as a solid.
後処理
- customThe catalyst was removed by filtration
- washwashed with methanol
- concentrationThe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-8af8fec5ffe04f169a2c46c97d195778
- 出典データセット
- uspto-grants-2012_05
- 特許番号
- US08178131B2
反応ノート
読み込み中…