Hydrochloric Acid → HCID 40427065、化合物
反応式
[NH2:1][C@@H:2]([CH2:6][C:7]1[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=1)[C:3]([OH:5])=[O:4].Cl>C(O)C.O=[Pt]=O>[NH2:1][C@@H:2]([CH2:6][CH:7]1[CH2:8][CH2:9][NH:10][CH2:11][CH2:12]1)[C:3]([OH:5])=[O:4]参加物
5
実験手順
To a solution of (2S)-2-amino-3-(pyridin-4-yl)propanoic acid LXXIII (660 mg, 4.0 mmol) in ethanol (120 mL) was added 1 N HCl (10 mL) and PtO2 (150 mg). The mixture was vigorously shaken 70 psi H2 in a Parr apparatus for 48 h. The mixture was filtered through Celite and the filtrate was concentrated to dryness giving crude (2S)-2-amino-3-(piperidin-4-yl)propanoic acid LXXIV as the hydrochloride salt (988 mg). ESIMS found for C8H16NO2 m/z 172.0 (M+).
後処理
- customfor 48 h
- filtrationThe mixture was filtered through Celite
- concentrationthe filtrate was concentrated to dryness
出典と根拠
- ORDレコード
- ord-84ec602eb2424276bde373477954dd28
- 出典データセット
- uspto-grants-2012_05
- 特許番号
- US08178490B2
反応ノート
読み込み中…