Water → (2-Oxo-4-propylpyrrolidin-1-yl)methyl diethylcarbamate

HRID 1924211

反応式

HRID 1924211 の反応式
[OH:1][CH2:2][N:3]1[CH2:7][CH:6]([CH2:8][CH2:9][CH3:10])[CH2:5][C:4]1=[O:11].C(N(CC)CC)C.[CH2:19]([N:21]([CH2:25][CH3:26])[C:22](Cl)=[O:23])[CH3:20].O>C(Cl)Cl>[CH2:19]([N:21]([CH2:25][CH3:26])[C:22](=[O:23])[O:1][CH2:2][N:3]1[CH2:7][CH:6]([CH2:8][CH2:9][CH3:10])[CH2:5][C:4]1=[O:11])[CH3:20]

参加物

6

反応物 4

HCID 962WaterHCID 6916Diethylcarbamoyl chlorideHCID 8471TriethylamineHCID 113326021-(Hydroxymethyl)-4-propylpyrrolidin-2-one

生成物 1

HCID 11448237(2-Oxo-4-propylpyrrolidin-1-yl)methyl diethylcarbamate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒3 回

実験手順

To a solution of 1-(hydroxymethyl)-4-propylpyrrolidin-2-one x2 (4 g, 25.44 mmol) and triethylamine (1.2 eq, 30.53 mmol, 3.089 g, 4.26 ml) in CH2Cl2 (25 ml) is added dropwise a solution of diethylcarbamyl chloride (1.1 eq, 27.99 mmol, 3.795 g, 3.55 ml) in CH2Cl2 (5 ml) at room temperature. The reaction mixture is allowed to react under agitation and inert atmosphere overnight. Hydrolysis (15 ml of water), extraction (CH2Cl2), drying of the combinated organic layers (MgSO4), filtration and solvent evaporation under reduced pressure gives (2-oxo-4-propylpyrrolidin-1-yl)methyl diethylcarbamate x6 (100%) which is used without any further purification.

後処理

  1. customto react under agitation and inert atmosphere overnight
  2. dry with materialdrying of the combinated organic layers (MgSO4), filtration and solvent evaporation under reduced pressure

出典と根拠

ORDレコード
ord-bd5c6b7ab8124f49ac230ea290da003e
出典データセット
uspto-grants-2012_05
特許番号
US08178533B2

関連ノート

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