Ethyl chloroacetate → ethyl 2-(1-methyl-2,6-dioxo-2,3-dihydro-1H-purin-7(6H)-yl)acetate

温度

90 °C

To a solution of 1-methyl xanthine (120, 1 g, 6.01 mmol) in DMF, potassium carbonate (0.91 g, 6.6 mmol) was added and the reaction mixture was heated to 90° C. and stirred for 1 h. A solution of ClCH2COOEt (0.36 g, 3.0 mmol) in DMF was then added dropwise to the reaction over 45 min. After stirring an additional 15 min, the reaction was cooled to room temperature and poured into ice cold 1N HCl (50 ml). The reaction was then extracted with chloroform (50×2 ml). The combined organic layers were washed with water (100 mL), dried over Na2SO4 and concentrated in vacuo. To the resulting solid was added 30% dichloromethane in hexanes (400 mL) and the resulting mixture was stirred for 15 min and filtered to yield compound 121 as a yellow solid (0.6 g, 40%). MS (APCI): m/z 253.32 [M+H]+.

1. stirringAfter stirring an additional 15 min
2. temperaturethe reaction was cooled to room temperature
3. extractionThe reaction was then extracted with chloroform (50×2 ml)
4. washThe combined organic layers were washed with water (100 mL)
5. dry with materialdried over Na2SO4
6. concentrationconcentrated in vacuo
7. additionTo the resulting solid was added 30% dichloromethane in hexanes (400 mL)
8. stirringthe resulting mixture was stirred for 15 min
9. filtrationfiltered

ORDレコード

ord-3328e48139274ba4aada2663f9890a2f

出典データセット

uspto-grants-2012_05

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08178542B2