(3-Chloro-2-methylphenyl)hydrazine → 3-[2-(3-Chloro-2-methyl-phenyl)-2H-pyrazol-3-yl]-1-(3-trifluoromethoxy-phenyl)-1H-pyridazin-4-one

HRID 1924528

反応式

HRID 1924528 の反応式
C[N:2](C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([O:20][C:21]([F:24])([F:23])[F:22])[CH:15]=2)[N:8]=1)=O.[Cl:26][C:27]1[C:28]([CH3:35])=[C:29]([NH:33]N)[CH:30]=[CH:31][CH:32]=1>>[Cl:26][C:27]1[C:28]([CH3:35])=[C:29]([N:33]2[C:5]([C:7]3[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]4[CH:19]=[CH:18][CH:17]=[C:16]([O:20][C:21]([F:24])([F:23])[F:22])[CH:15]=4)[N:8]=3)=[CH:4][CH:3]=[N:2]2)[CH:30]=[CH:31][CH:32]=1

参加物

3

反応物 2

HCID 702863(3-Chloro-2-methylphenyl)hydrazineHCID 593701233-((E)-3-Dimethylamino-acryloyl)-1-(3-trifluoromethoxy-phenyl)-1H-pyridazin-4-one

生成物 1

HCID 462200443-[2-(3-Chloro-2-methyl-phenyl)-2H-pyrazol-3-yl]-1-(3-trifluoromethoxy-phenyl)-1H-pyridazin-4-one

実験手順

Reaction of 3-((E)-3-dimethylamino-acryloyl)-1-(3-trifluoromethoxy-phenyl)-1H-pyridazin-4-one (A-6) and (3-chloro-2-methyl-phenyl)-hydrazine according to example 43 gave the desired product. MS: M=447.3 (M+H)+

出典と根拠

ORDレコード
ord-18a8e2a6feab452eb76093dab2f082e9
出典データセット
uspto-grants-2012_05
特許番号
US08178538B2

関連ノート

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