Acrolein → 3-[5-(3-methyl-4-isothiazolyl)-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]propanal

反応式

[CH3:1][C:2]1[C:6]([C:7]2[C:8](=[O:14])[NH:9][C:10](=[O:13])[NH:11][CH:12]=2)=[CH:5][S:4][N:3]=1.C(N(CC)CC)C.[CH:22]([CH:24]=[CH2:25])=[O:23]>CN(C)C=O>[CH3:1][C:2]1[C:6]([C:7]2[C:8](=[O:14])[NH:9][C:10](=[O:13])[N:11]([CH2:25][CH2:24][CH:22]=[O:23])[CH:12]=2)=[CH:5][S:4][N:3]=1

参加物

実験手順

5-(3-methyl-4-isothiazolyl)-2,4(1H,3H)-pyrimidinedione (Pre 47, 0.126 mmol) was dissolved in N,N-Dimethylformamide (DMF) (1 ml). TRIETHYLAMINE (0.021 ml, 0.151 mmol) was added and the mixture was stirred at room temperature for 5 minutes. Acrolein (8.42 μl, 0.126 mmol) was added and the mixture was stirred at room temperature monitoring the reaction progression by LCMS. After 7 hrs Acrolein (3 μl) was added and the mixture was stirred at rt overnight.