Water → HCID 67427009、化合物

HRID 1925183ノート

反応式

HRID 1925183 の反応式
[CH2:1]([CH:3]([CH2:39][CH3:40])[CH2:4][C:5]1([C:11]([NH:13][C:14]2[C:15]([S:24]C(C3(CC(CC)CC)CCCCC3)=O)=[CH:16][C:17]3[C:22]([CH:23]=2)=[CH:21][CH:20]=[CH:19][CH:18]=3)=[O:12])[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1)[CH3:2].[OH-].[K+].O>CO.O1CCCC1>[SH:24][C:15]1[C:14]([NH:13][C:11]([C:5]2([CH2:4][CH:3]([CH2:39][CH3:40])[CH2:1][CH3:2])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10]2)=[O:12])=[CH:23][C:22]2[C:17]([CH:16]=1)=[CH:18][CH:19]=[CH:20][CH:21]=2

参加物

6

反応物 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 86642989HCID 86642989、化合物

生成物 1

HCID 67427009HCID 67427009、化合物

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

The crude product obtained in step A) is dissolved in a mixture of methanol and tetra-hydrofuran (1:1). Then 3.5 mol equivalents of potassium hydroxide are added at room temperature and the mixture is stirred for 1 hour. Then water is added and the mixture is washed with n-hexane. The aqueous layer is then acidified by addition of KHSO4 and extracted with chloroform. The combined extracts are washed with water and brine, dried (Na2SO4) and concentrated to obtain 1-(2-ethyl-butyl)-cyclohexanecarboxylic acid (3-mercapto-naphthalen-2-yl)-amide.

後処理

  1. washthe mixture is washed with n-hexane
  2. additionThe aqueous layer is then acidified by addition of KHSO4
  3. extractionextracted with chloroform
  4. washThe combined extracts are washed with water and brine
  5. dry with materialdried (Na2SO4)
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-1b21271a842349d18c360f39d56ff149
出典データセット
uspto-grants-2012_05
特許番号
US08178583B2

反応ノート

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