Hydrochloric Acid → 5-Fluoro-6-hydroxynaphthalene-1-carboxylic acid

HRID 1925362ノート

反応式

HRID 1925362 の反応式
[OH-].[Na+].[F:3][C:4]1[C:13]([OH:14])=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][CH:8]=[C:9]2[C:15]([O:17]C)=[O:16].Cl>O.CO>[F:3][C:4]1[C:13]([OH:14])=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][CH:8]=[C:9]2[C:15]([OH:17])=[O:16]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 24823729Methyl 5-fluoro-6-hydroxynaphthalene-1-carboxylate

生成物 1

HCID 248246045-Fluoro-6-hydroxynaphthalene-1-carboxylic acid

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

Sodium hydroxide (116 g, 2.9 mol) was dissolved in 100 mL water and added to a solution of methyl 5-fluoro-6-hydroxy-1-naphthoate (8.56 g, 38.9 mmol) in methanol (200 mL). The mixture was refluxed at 80° C. for 2 h. The mixture was allowed to cool to RT, then poured into 6N HCl in ice. The pH was adjusted to 3 to give a fine purple/pink solid. The title compound was isolated by centrifuge (with some salts).

後処理

  1. temperatureto cool to RT
  2. customto give a fine purple/pink solid

出典と根拠

ORDレコード
ord-a1ef9a602ed64e72b2fa796ab2c0135e
出典データセット
uspto-grants-2012_05
特許番号
US08178557B2

反応ノート

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