HCID 3522175、化合物 → 2-(4-Aminophenyl)-1-(4-methylpiperazin-1-yl)ethan-1-one

HRID 1925387ノート

反応式

HRID 1925387 の反応式
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8](=[O:19])[CH2:9][C:10]2[CH:15]=[CH:14][C:13]([N+:16]([O-])=O)=[CH:12][CH:11]=2)[CH2:4][CH2:3]1.[H][H]>CCO.[Pd]>[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([C:8]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][CH:11]=2)=[O:19])[CH2:6][CH2:7]1

参加物

5

反応物 2

HCID 3522175HCID 3522175、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 167730792-(4-Aminophenyl)-1-(4-methylpiperazin-1-yl)ethan-1-one

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A solution of 1-methyl-4-[(4-nitrophenyl)acetyl]piperazine (1.5 g, 5.70 mmol) in EtOH (30 mL) was reduced over palladium/charcoal (10% wt, 50% wet, 150 mg) with hydrogen under atmospheric pressure and RT for 18 h. The catalyst was separated by filtration through Celite® and the solvent evaporated to the title compound as a brown oil, 1.12 g.

後処理

  1. customThe catalyst was separated by filtration through Celite®
  2. customthe solvent evaporated to the title compound as a brown oil, 1.12 g

出典と根拠

ORDレコード
ord-d76bb9487ff64392b6800777ef0332fb
出典データセット
uspto-grants-2012_05
特許番号
US08178557B2

反応ノート

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