Sec-Butylbenzene → 4-(Butan-2-yl)benzene-1-sulfonyl chloride

温度

80 °C

To a solution of commercially available sec-butylbenzene (1.34 g; 10 mmol) in 1,2-dichloroethane (50 mL) was added phosphorus pentachloride (2.5 g; 12 mmol) followed by chlorosulfonic acid (1.3 mL; 20 mmol) slowly. The mixture was heated at 80° C. overnight, then cooled to room temperature and mixed with ice water (150 mL). The organic phase was separated, and the aqueous phase was extracted with dichloromethane (2×10 mL). The organic phases were combined and dried over magnesium sulfate and concentrated under reduced pressure to give an orange oil which was used without further purification (2.3 g).

1. temperaturecooled to room temperature
2. customThe organic phase was separated
3. extractionthe aqueous phase was extracted with dichloromethane (2×10 mL)
4. dry with materialdried over magnesium sulfate
5. concentrationconcentrated under reduced pressure
6. customto give an orange oil which
7. customwas used without further purification (2.3 g)

ORDレコード

ord-b8e394d90157493fba6a2bb1d270ca01

出典データセット

uspto-grants-2012_05

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08178699B2