Chlorosulfonic acid → HCID 59180464、化合物
反応式
[C:1]1([CH3:12])[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]1[CH2:11][CH2:10][CH2:9][CH2:8]1.Cl[S:14]([OH:17])(=[O:16])=[O:15]>ClCCl>[CH3:12][C:1]1[CH:6]=[C:5]([S:14]([OH:17])(=[O:16])=[O:15])[CH:4]=[CH:3][C:2]=1[N:7]1[CH2:11][CH2:10][CH2:9][CH2:8]1参加物
4
実験手順
To a cooled (0° C.) solution of 119 (1.24 g; 7.7 mmol) in anhydrous dichloromethane (38 mL) was added chlorosulfonic acid (0.61 mL; 9.24 mmol) dropwise (1 mL/minutes). The reaction mixture w as allowed to gradually warm to room temperature while stirring overnight. The reaction mixture was concentrated under reduced pressure. The resulting oil w as taken up in diisopropyl ether (10 mL) and aqueous hydrochloric acid (0.5 mL; 2N) then stirred vigorously at room temperature for 2 hours. The organic phase was separated and concentrated under reduced pressure to yield the desired compound as an amber oil (1.8 g).