5-Tert-butyl-m-xylene → 4-tert-butyl-2,6-dimethylbenzenesulfonyl chloride
反応式
[C:1]([C:5]1[CH:10]=[C:9]([CH3:11])[CH:8]=[C:7]([CH3:12])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[Cl:13][S:14](O)(=[O:16])=[O:15]>ClCCl>[C:1]([C:5]1[CH:6]=[C:7]([CH3:12])[C:8]([S:14]([Cl:13])(=[O:16])=[O:15])=[C:9]([CH3:11])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2]参加物
4
実験手順
Synthesized as described for 1 using 1-tert-butyl-3,5-dimethylbenzene (5.76 mL; 30.81 mmol), chlorosulfonic acid (2.46 mL; 36.96 mmol) and anhydrous dichloromethane (200 mL). The crude residue was purified by automated silica gel column chromatography (Biotage®) eluting with ethyl acetate/hexanes (0 to 25% v/v gradient elution over 400 mL) to give the title compound as a white solid (1.60 g).
後処理
- customSynthesized
- customThe crude residue was purified by automated silica gel column chromatography (Biotage®)
- washeluting with ethyl acetate/hexanes (0 to 25% v/v gradient elution over 400 mL)
出典と根拠
- ORDレコード
- ord-5a74a4b7dea942b0bbc17f178f9a9026
- 出典データセット
- uspto-grants-2012_05
- 特許番号
- US08178699B2
反応ノート
読み込み中…