2-[4-(Hydroxymethyl)-2,6-dimethoxyphenoxy]ethan-1-ol → HCID 19622754、化合物
反応式
[OH:1][CH2:2][C:3]1[CH:12]=[C:11]([O:13][CH3:14])[C:6]([O:7][CH2:8][CH2:9][OH:10])=[C:5]([O:15][CH3:16])[CH:4]=1>C(Cl)Cl.O=[Mn]=O>[OH:10][CH2:9][CH2:8][O:7][C:6]1[C:11]([O:13][CH3:14])=[CH:12][C:3]([CH:2]=[O:1])=[CH:4][C:5]=1[O:15][CH3:16]参加物
4
実験手順
To a solution of 2-(4-hydroxymethyl-2,6-dimethoxyphenoxy)ethanol (1.78 g, 7.8 mmol) in methylene chloride (39 mL, 0.2 M) was added MnO2 (6.8 g, 78 mmol). The reaction mixture was stirred for 3 hours at room temperature, then subjected to celite filtration, and evaporated under reduced pressure. Recrystallization of the residue from diethyl ether gave a colorless granular crystal (1.586 g, 89.8%, m.p. 69 to 70° C.).
後処理
- filtrationsubjected to celite filtration
- customevaporated under reduced pressure
- customRecrystallization of the residue from diethyl ether
出典と根拠
- ORDレコード
- ord-74b1f69d9ead44e7a2d108fbb0a7f201
- 出典データセット
- uspto-grants-2012_05
- 特許番号
- US08178727B2
反応ノート
読み込み中…