Formamidine acetate → 6-(furan-2-yl)-5H-pyrrolo[3,2-d]pyrimidin-4-ol
反応式
[NH2:1][C:2]1[CH:6]=[C:5]([C:7]2[O:8][CH:9]=[CH:10][CH:11]=2)[NH:4][C:3]=1[C:12]([O:14]CC)=O.C(O)(=O)C.[CH:21](N)=[NH:22]>C(O)C>[O:8]1[CH:9]=[CH:10][CH:11]=[C:7]1[C:5]1[NH:4][C:3]2[C:12](=[O:14])[NH:22][CH:21]=[N:1][C:2]=2[CH:6]=1参加物
4
実験手順
To a solution of ethyl 3-amino-5-(2-furyl)-1H-pyrrole-2-carboxylate (2.58 g) in ethanol (35 mL) was added formamidine acetate (1.83 g), and the mixture was heated under reflux for 18 hrs. After cooling to room temperature, the precipitated solid was collected by filtration, washed with ethanol, and dried under reduced pressure at 60° C. to give the title compound (2.26 g).
後処理
- temperaturethe mixture was heated
- temperatureunder reflux for 18 hrs
- filtrationthe precipitated solid was collected by filtration
- washwashed with ethanol
- customdried under reduced pressure at 60° C.
出典と根拠
- ORDレコード
- ord-0892badb54c14fb6b553e8368b245712
- 出典データセット
- uspto-grants-2012_05
- 特許番号
- US08178543B2
反応ノート
読み込み中…