HCID 44540433、化合物 → HCID 44540435、化合物

HRID 1926203ノート

反応式

HRID 1926203 の反応式
[N+:1]([C:4]1[CH:16]=[CH:15][C:14]2[C:13]3[C:8](=[CH:9][C:10]([N+:17]([O-])=O)=[CH:11][CH:12]=3)[C:7](=[CH:20][C:21]([NH:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][C:29]([NH:31][C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=3[NH2:38])=[O:30])=[O:22])[C:6]=2[CH:5]=1)([O-])=O.[H][H]>CO.[Pd]>[NH2:17][C:10]1[CH:11]=[CH:12][C:13]2[C:14]3[C:6](=[CH:5][C:4]([NH2:1])=[CH:16][CH:15]=3)[C:7](=[CH:20][C:21]([NH:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][C:29]([NH:31][C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=3[NH2:38])=[O:30])=[O:22])[C:8]=2[CH:9]=1

参加物

5

反応物 2

HCID 44540433HCID 44540433、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 44540435HCID 44540435、化合物収率 96%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of 6-(2-(2,7-dinitro-9H-fluoren-9-ylidene)acetamido)-N-(2-aminophenyl)-hexanamide (515 mg, 1 mmol) in methanol (20 ml) was added 5% palladium on charcoal (0.50 g). Then the mixture was stirred under an atmosphere of hydrogen at room temperature until hydrogen uptake ceased. The solution was filtered through celite, and the filtrate was evaporated under vacuum to give the title compound (437 mg, 96% yield) as a white solid. LC-MS (m/z) 456 (M+1).

後処理

  1. filtrationThe solution was filtered through celite
  2. customthe filtrate was evaporated under vacuum

出典と根拠

ORDレコード
ord-ddb350a83df84cd4b31e0e66bffcfcb5
出典データセット
uspto-grants-2012_05
特許番号
US08178577B2

反応ノート

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