2-Methyl-8-nitroquinoline → 2-Methyl-8-aminoquinoline

HRID 1926539

反応式

HRID 1926539 の反応式
[N+:1]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:13]=1[N:12]=[C:11]([CH3:14])[CH:10]=[CH:9]2)([O-])=O>[Pd].C(O)C>[CH3:14][C:11]1[CH:10]=[CH:9][C:8]2[C:13](=[C:4]([NH2:1])[CH:5]=[CH:6][CH:7]=2)[N:12]=1

参加物

4

反応物 1

HCID 134332-Methyl-8-nitroquinoline

生成物 1

HCID 1404572-Methyl-8-aminoquinoline収率 99.9%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

To a Pressure reaction bottle was added 5.0 g of 8-nitroquinaldine, 0.5 g 5% palladium on carbon, and 150 ml ethanol. The mixture was purged with hydrogen and then hydrogenated under 40 psi hydrogen for 16 hours. The catalyst was filtered off on a bed of celite. The solvent was removed, resulting in 4.2 g of a dark oil.

後処理

  1. customTo a Pressure reaction bottle
  2. customThe mixture was purged with hydrogen
  3. filtrationThe catalyst was filtered off on a bed of celite
  4. customThe solvent was removed

出典と根拠

ORDレコード
ord-89f695c0d3fa4ffea39f48522a21f72b
出典データセット
uspto-grants-2012_05
特許番号
US08182718B2

関連ノート

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