Morpholine → 4-Chloro-2-morpholin-4-yl-1,3-thiazole-5-carbonitrile
反応式
Cl[C:2]1[S:3][C:4]([C:8]#[N:9])=[C:5]([Cl:7])[N:6]=1.C(N(CC)C(C)C)(C)C.[NH:19]1[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1>C(O)C.O>[Cl:7][C:5]1[N:6]=[C:2]([N:19]2[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)[S:3][C:4]=1[C:8]#[N:9]参加物
6
実験手順
2,4-dichloro-5-cyanothiazole (1.26 g, 0.00704 mol) and N,N-diisopropylethylamine (3.68 mL, 0.0211 mol) were dissolved in ethanol at 70° C. Morpholine (0.614 mL, 0.0704 mol) was added to the hot solution and the mixture was stirred for 30 minutes, cooled down to rt, diluted with water (50 mL) and the formed precipitate was collected to give the title compound (1.55 g, 91%). LCMS: (FA) ES+, 230. 1H NMR (300 MHz, d6-DMSO) δ: 3.71-3.67 (m, 4H), 3.52-3.48 (m, 4H).
後処理
- customthe formed precipitate was collected
出典と根拠
- ORDレコード
- ord-0d76a7410a6c4bdb80151477f28d2e66
- 出典データセット
- uspto-grants-2012_05
- 特許番号
- US08183240B2
反応ノート
読み込み中…