HCID 67131363、化合物 → 2-Cyclopropylpyrimidin-5-ol
反応式
C([O:8][C:9]1[CH:10]=[N:11][C:12]([CH:15]2[CH2:17][CH2:16]2)=[N:13][CH:14]=1)C1C=CC=CC=1>CO.[Pd]>[CH:15]1([C:12]2[N:13]=[CH:14][C:9]([OH:8])=[CH:10][N:11]=2)[CH2:17][CH2:16]1参加物
4
実験手順
5-(Benzyloxy)-2-cyclopropylpyrimidine (4.0 g, 18 mmol) was dissolved in MeOH (100 mL) and 10% palladium on carbon (0.170 g) was added. The mixture was hydrogenated at ambient temperature and 1.013 bar pressure overnight. Filtration and concentration gave a crude product that was filtered through a short silica gel column using 5% MeOH-EtOAc as eluent. Evaporation of the solvent gave 1.3 g (54% yield) of the subtitle compound as a colourless solid.
後処理
- customwas hydrogenated at ambient temperature
- custom1.013 bar pressure overnight
- filtrationFiltration and concentration
- customgave a crude product that
- filtrationwas filtered through a short silica gel column
- customEvaporation of the solvent
出典と根拠
- ORDレコード
- ord-c37667a588f2416da79dc4e9d8444c97
- 出典データセット
- uspto-grants-2012_05
- 特許番号
- US08183251B2
反応ノート
読み込み中…