1-{[(3-Nitropyridin-2-yl)amino]methyl}-4-propylpyrrolidin-2-one → 1-{[(3-Aminopyridin-2-yl)amino]methyl}-4-propylpyrrolidin-2-one

反応式

[N+:1]([C:4]1[C:5]([NH:10][CH2:11][N:12]2[CH2:16][CH:15]([CH2:17][CH2:18][CH3:19])[CH2:14][C:13]2=[O:20])=[N:6][CH:7]=[CH:8][CH:9]=1)([O-])=O>[Pd].O.CO>[NH2:1][C:4]1[C:5]([NH:10][CH2:11][N:12]2[CH2:16][CH:15]([CH2:17][CH2:18][CH3:19])[CH2:14][C:13]2=[O:20])=[N:6][CH:7]=[CH:8][CH:9]=1

参加物

実験手順

Palladium on charcoal (10% wt, 0.478 g) is added to a solution of 1-{[(3-nitropyridin-2-yl)amino]methyl}-4-propylpyrrolidin-2-one x77 (1 eq, 2.5 g, 8.983 mmol) and NH4CO2H (5 eq, 44.9 mmol, 2.832 g) in water and methanol (1/1 (v/v), 35 ml). The resulting slurry is kept under agitation during 16 hours at room temperature, then filtration over celite and evaporation of the crude mixture afford 2.524 g of 1-{[(3-aminopyridin-2-yl)amino]methyl}-4-propylpyrrolidin-2-one x78.