Potassium Carbonate → Methyl 6-{[5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]amino}hexanoate

反応式

Cl[C:2]1[C:3]2[C:10]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=3)=[CH:9][O:8][C:4]=2[N:5]=[CH:6][N:7]=1.Cl.[CH3:20][O:21][C:22](=[O:29])[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][NH2:28].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[CH3:20][O:21][C:22](=[O:29])[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][NH:28][C:2]1[C:3]2[C:10]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=3)=[CH:9][O:8][C:4]=2[N:5]=[CH:6][N:7]=1

参加物

実験手順

Dissolve 7.1 g (27.2 mol) 4-chloro-5-(4-methoxyphenyl)furo[2,3-d]pyrimidine in 250 ml acetonitrile and add 5.9 g (32.7 mmol) 6-aminohexanoic acid methyl ester hydrochloride and 9.4 g (68.1 mmol) potassium carbonate. Heat the mixture under reflux for 18 hours and then filter after cooling to room temperature. Mix the residue three times in 50 ml water each time, filter and dry under vacuum. 4.1 g (41% of theor.) of the title compound is obtained.