Hydrochloric Acid → 6-{[6-(4-Fluorophenyl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]amino}hexanoic acid

HRID 1926973ノート

反応式

HRID 1926973 の反応式
[OH-].[Na+].C[O:4][C:5](=[O:36])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:12]1[C:13]2[C:20]([C:21]3[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=3)=[C:19]([C:29]3[CH:34]=[CH:33][C:32]([F:35])=[CH:31][CH:30]=3)[O:18][C:14]=2[N:15]=[CH:16][N:17]=1.Cl>O1CCOCC1>[F:35][C:32]1[CH:33]=[CH:34][C:29]([C:19]2[O:18][C:14]3[N:15]=[CH:16][N:17]=[C:12]([NH:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][C:5]([OH:36])=[O:4])[C:13]=3[C:20]=2[C:21]2[CH:22]=[CH:23][C:24]([O:27][CH3:28])=[CH:25][CH:26]=2)=[CH:30][CH:31]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 580169116-{[6-(4-Fluorophenyl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]amino}hexanoic acid methyl ester

生成物 1

HCID 580168856-{[6-(4-Fluorophenyl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]amino}hexanoic acid

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

Add 1 ml 1 N sodium hydroxide solution to a solution of 169 mg (0.37 mmol) 6-{[6-(4-fluorophenyl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]amino}hexanoic acid methyl ester in 5 ml dioxan and stir for 16 h at RT. After adding 3 ml 1 N hydrochloric acid, concentrate the reaction solution by vacuum evaporation. Mix the residue with diethyl ether, filter, and dry under vacuum. 165 mg (99% of theor.) of the desired product is obtained.

後処理

  1. concentrationconcentrate the reaction solution
  2. customby vacuum evaporation
  3. additionMix the residue with diethyl ether
  4. filtrationfilter
  5. customdry under vacuum

出典と根拠

ORDレコード
ord-0645248e454143a79e6cc0f5339c0703
出典データセット
uspto-grants-2012_05
特許番号
US08183246B2

反応ノート

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