Propionic Acid → HCID 86636877、化合物

HRID 1927184ノート

反応式

HRID 1927184 の反応式
[NH2:1][C:2]1[C:7]([NH:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:6][CH:5]=[C:4]([NH:14][CH2:15][C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)[N:3]=1.[C:23]([OH:27])(=[O:26])[CH2:24][CH3:25]>C(O)(C)C>[CH3:13][CH2:12][O:11][C:9]([NH:8][C:7]1[CH:6]=[CH:5][C:4]([NH:14][CH2:15][C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)=[N:3][C:2]=1[NH2:1])=[O:10].[C:23]([O-:27])(=[O:26])[CH2:24][CH3:25]

参加物

4

反応物 2

HCID 1032Propionic AcidHCID 53276Flupirtine

生成物 1

HCID 86636877HCID 86636877、化合物

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

反応条件

温度
60 °C

実験手順

Under nitrogen atmosphere 30 g of 2-amino-3-carbethoxyamino-6-(4-fluoro-benzylamino)-pyridine and 7.5 g of propionic acid were added to 500 ml of isopropanol. The mixture was heated to 60° C. A transparent solution of flupirtine propionate was formed and was kept for 30 min at 50° C. The solution was filtered at 20° C. and crystallisation occurred while cooling the solution down to −5° C. for 12 h. The product was collected by filtration and dried at reduced pressure at room temperature for 12 h. As a result of drying 25 g white crystals of the product were obtained.

出典と根拠

ORDレコード
ord-0a8a6cea9d06461389753bb5780152c1
出典データセット
uspto-grants-2012_05
特許番号
US08183267B2

反応ノート

読み込み中…