Ammonium Chloride → 3-(2H-Tetrazol-5-yl)pyridin-2-amine
反応式
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[N-:10]=[N+:11]=[N-:12].[Na+].[Cl-].[NH4+]>CN(C=O)C>[NH3:1].[N:9]1[NH:10][N:11]=[N:12][C:8]=1[C:7]1[C:2]([NH2:1])=[N:3][CH:4]=[CH:5][CH:6]=1参加物
6
実験手順
2-Amino-3-cyanopyridine (1.0 g), sodium azide (1.1 g), ammonium chloride (0.89 g), and DMF (15 mL) were stirred for 1.5 hours at 100° C. The reaction solution was directly purified by silica gel chromatography (ethyl acetate, then ethyl acetate:methanol:concentrated aqueous ammonia=6:2:0.5) to obtain the titled compound (0.66 g).
後処理
- customThe reaction solution was directly purified by silica gel chromatography (ethyl acetate
出典と根拠
- ORDレコード
- ord-8b6edd4ad69248b780c40b246768fcaf
- 出典データセット
- uspto-grants-2012_05
- 特許番号
- US08183264B2
反応ノート
読み込み中…