Ethanol → (3-(5-Methyl-thiophen-2-ylmethyl)-phenyl)-methanol
反応式
C(O)C.[CH3:4][C:5]1[S:9][C:8]([CH2:10][C:11]2[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=2)[CH:14]=[O:15])=[CH:7][CH:6]=1.[BH4-].[Na+]>O>[CH3:4][C:5]1[S:9][C:8]([CH2:10][C:11]2[CH:12]=[C:13]([CH2:14][OH:15])[CH:16]=[CH:17][CH:18]=2)=[CH:7][CH:6]=1参加物
5
実験手順
To a solution of ethanol (5.0 mL) and 3-(5-methyl-thiophen-2-ylmethyl)-benzaldehyde (350 mg) described in Manufacturing Example 52-2 was added sodium borohydride (120 mg), which was stirred for 10 minutes at room temperature. Water was added to the reaction solution, which was then extracted with ethyl acetate. The solvent was evaporated from the organic layer under a reduced pressure, and the residue was purified by silica gel chromatography (heptane:ethyl acetate=2:1) to obtain the titled compound (300 mg).
後処理
- extractionwas then extracted with ethyl acetate
- customThe solvent was evaporated from the organic layer under a reduced pressure
- customthe residue was purified by silica gel chromatography (heptane:ethyl acetate=2:1)
出典と根拠
- ORDレコード
- ord-6b304798ff4a446cace12547705eb42e
- 出典データセット
- uspto-grants-2012_05
- 特許番号
- US08183264B2
反応ノート
読み込み中…