Sodium Sulfite → HCID 178506558、化合物

HRID 1927684ノート

反応式

HRID 1927684 の反応式
[I:1][C:2]1[N:3]=[C:4]([CH2:8][CH2:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=3)=[CH:12][CH:11]=2)[NH:5][C:6]=1I.S([O-])([O-])=O.[Na+].[Na+]>C(O)C.O>[I:1][C:2]1[N:3]=[C:4]([CH2:8][CH2:9][C:10]2[CH:11]=[CH:12][C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=3)=[CH:14][CH:15]=2)[NH:5][CH:6]=1

参加物

5

反応物 2

HCID 24437Sodium SulfiteHCID 686726842-[4-[2-(4,5-diiodo-1H-imidazol-2-yl)ethyl]phenyl]pyridine

生成物 1

HCID 178506558HCID 178506558、化合物

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

A solution of 2-{4-[2-(4,5-diiodo-1H-imidazol-2-yl)ethyl]phenyl}pyridine (11.2 g, 22.4 mmol) and sodium sulfite (3.1 g, 24.7 mmol) in ethanol (200 mL) and water (200 mL) was heated at 100° C. for 2 days. The reaction mixture was concentrated to half its original volume and partitioned between ethyl acetate and water. The organic phase was separated and concentrated in vacuo to afford 2-{4-[2-(4-iodo-1H-imidazol-2-yl)ethyl]phenyl}pyridine, which was used without further purification.

後処理

  1. concentrationThe reaction mixture was concentrated to half its original volume
  2. custompartitioned between ethyl acetate and water
  3. customThe organic phase was separated
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-7e1f3486b3574dbf93eccbfcd40d8f67
出典データセット
uspto-grants-2012_05
特許番号
US08183275B2

反応ノート

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