Phosphorus oxybromide → 2-Bromo-6-methyl-4-(4-trifluoromethyl-phenyl)-pyridine
反応式
[CH3:1][C:2]1[NH:7][C:6](=O)[CH:5]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[CH:3]=1.P(Br)(Br)([Br:21])=O>>[Br:21][C:6]1[CH:5]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[CH:3]=[C:2]([CH3:1])[N:7]=1参加物
3
実験手順
The title compound was prepared from 6-methyl-4-(4-trifluoromethyl-phenyl)-1H-pyridin-2-one (example A.30 step 1) (118.1 g, 466.4 mmol) and phosphoryl bromide (267.4 g, 933 mmol) according to the general procedure Ia to d preparation of bromides. Obtained as an off-white solid (109.67 g, 74%). MS (ISP) 316.0 [(M+H)+] and 318.0 [(M+2+H)+]; mp 74-76° C.
出典と根拠
- ORDレコード
- ord-94183717481442ff8aeb97b0a8d03bb0
- 出典データセット
- uspto-grants-2012_05
- 特許番号
- US08183262B2
反応ノート
読み込み中…