Triethylamine → 1-{4-[2-(2-Fluorophenoxy)ethyl]piperazin-1-yl}-3-(3,4,5-trimethoxyphenyl)propan-1-one hydrochloride

HRID 1928547

反応式

HRID 1928547 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:13][CH2:14][C:15]([OH:17])=O)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].C1C=CC2N(O)N=NC=2C=1.CCN=C=NCCCN(C)C.[ClH:39].[F:40][C:41]1[CH:55]=[CH:54][CH:53]=[CH:52][C:42]=1[O:43][CH2:44][CH2:45][N:46]1[CH2:51][CH2:50][NH:49][CH2:48][CH2:47]1.C(N(CC)CC)C>CN(C=O)C.O>[ClH:39].[F:40][C:41]1[CH:55]=[CH:54][CH:53]=[CH:52][C:42]=1[O:43][CH2:44][CH2:45][N:46]1[CH2:47][CH2:48][N:49]([C:15](=[O:17])[CH2:14][CH2:13][C:5]2[CH:6]=[C:7]([O:11][CH3:12])[C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=2)[CH2:50][CH2:51]1

参加物

8

反応物 5

HCID 8471TriethylamineHCID 648603,4,5-Trimethoxyhydrocinnamic acidHCID 757711-HydroxybenzotriazoleHCID 7627031-[2-(2-Fluorophenoxy)ethyl]piperazineHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride

生成物 1

HCID 672988021-{4-[2-(2-Fluorophenoxy)ethyl]piperazin-1-yl}-3-(3,4,5-trimethoxyphenyl)propan-1-one hydrochloride収率 56.3%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

To a mixture of 3-(3,4,5-trimethoxyphenyl)propionic acid (0.36 g, 1.5 mmol), HOBt (0.24 g, 1.8 mmol), EDAC.HCl (0.34 g, 1.8 mmol) in DMF (4 mL) was added 1-[2-(2-fluoro-phenoxy)ethyl]piperazine (0.34 g, 1.5 mmol) and triethylamine (0.5 mL, 3.6 mmol). The mixture was then stirred at room temperature for a day, treated with water, and extracted with dichloromethane. The organic layer was washed with water and brine and then concentrated to dryness. The residue was dissolved in ethyl ether and was added with 2N HCl in ether (1 mL). The white solid was filtered and dried under vacuum to give the title compound (408 mg, 52%).

後処理

  1. extractionextracted with dichloromethane
  2. washThe organic layer was washed with water and brine
  3. concentrationconcentrated to dryness
  4. dissolutionThe residue was dissolved in ethyl ether
  5. additionwas added with 2N HCl in ether (1 mL)
  6. filtrationThe white solid was filtered
  7. customdried under vacuum

出典と根拠

ORDレコード
ord-6695f11e100e428a9c8dd487a00325d2
出典データセット
uspto-grants-2012_05
特許番号
US08183374B2

関連ノート

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