Triphosgene → 1-[2-((R)-Indan-1-ylamino)-quinolin-6-yl]-3-(tetrahydro-pyran-4-yl)-urea

HRID 1928722ノート

反応式

[C:1](=[O:12])(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl.[NH2:13][CH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1.[C@H:20]1([NH:29][C:30]2[CH:39]=[CH:38][C:37]3[C:32](=[CH:33][CH:34]=[C:35]([NH2:40])[CH:36]=3)[N:31]=2)[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH2:22][CH2:21]1>>[C@H:20]1([NH:29][C:30]2[CH:39]=[CH:38][C:37]3[C:32](=[CH:33][CH:34]=[C:35]([NH:40][C:1]([NH:13][CH:14]4[CH2:19][CH2:18][O:17][CH2:16][CH2:15]4)=[O:12])[CH:36]=3)[N:31]=2)[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH2:22][CH2:21]1

参加物

反応物 3

HCID 94429Triphosgene

HCID 4192234-Aminotetrahydropyran

HCID 57860958(R)-N2-Indan-1-yl-quinoline-2,6-diamine

生成物 1

HCID 442174701-[2-((R)-Indan-1-ylamino)-quinolin-6-yl]-3-(tetrahydro-pyran-4-yl)-urea

実験手順

The title compound was prepared in accordance with the general method 4 described in example 16 from bis(trichloromethyl) carbonate, 4-aminotetrahydropyran and (R)—N2-indan-1-yl-quinoline-2,6-diamine; MS: m/e=403.5 (M+H+).

出典と根拠

ORDレコード: ord-eeed91b3f1e94eb68d899d322af62e75
出典データセット: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08183380B2

反応ノート

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