Triphosgene → 1-[2-(8-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-ylamino)-quinolin-6-yl]-3-((r)-1-methyl-pyrrolidin-3-yl)-urea
反応式
[C:1](=O)(OC(Cl)(Cl)Cl)[O:2]C(Cl)(Cl)Cl.[CH3:13][N:14]1[CH2:18][CH2:17][C@@H:16]([NH2:19])[CH2:15]1.[CH3:20][O:21][C:22]1[CH:23]=[CH:24][CH:25]=[C:26]2[C:31]=1[CH:30]([NH:32][C:33]1[CH:42]=[CH:41][C:40]3[C:35](=[CH:36][CH:37]=[C:38]([NH2:43])[CH:39]=3)[N:34]=1)[CH2:29][CH2:28][CH2:27]2>>[CH3:20][O:21][C:22]1[CH:23]=[CH:24][CH:25]=[C:26]2[C:31]=1[CH:30]([NH:32][C:33]1[CH:42]=[CH:41][C:40]3[C:35](=[CH:36][CH:37]=[C:38]([NH:43][C:1]([NH:19][C@@H:16]4[CH2:17][CH2:18][N:14]([CH3:13])[CH2:15]4)=[O:2])[CH:39]=3)[N:34]=1)[CH2:29][CH2:28][CH2:27]2参加物
4
実験手順
The title compound was prepared in accordance with the general method 4 described in example 16 from bis(trichloromethyl) carbonate, (3R)-1-methyl-3-pyrrolidinamine (CAS no: 457097-75-5) and rac-N2-(8-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-quinoline-2,6-diamine; MS: m/e=446.4 (M+H+).