Sodium Hydroxide → (3R,4R)-3-methylpiperidin-4-yl pivalate
反応式
[CH3:1][C@@H:2]1[C@@H:7]([O:8][C:9](=[O:14])[C:10]([CH3:13])([CH3:12])[CH3:11])[CH2:6][CH2:5][NH:4][CH2:3]1.[OH-].[Na+]>>[CH3:1][C@H:2]1[C@H:7]([O:8][C:9](=[O:14])[C:10]([CH3:13])([CH3:12])[CH3:11])[CH2:6][CH2:5][NH:4][CH2:3]1参加物
3
実験手順
The mother liquor of 17 from above is treated with 1N-NaOH to obtain the free base which is then crystallized with D-(+)-O,O′-Dibenzoyl tartaric acid as described above to give the antipode 20.
後処理
- customto obtain the free base which
- customis then crystallized with D-(+)-O,O′-Dibenzoyl tartaric acid
- customto give the antipode 20
出典と根拠
- ORDレコード
- ord-6f2a25e861ee4cca9dbb627ef491ca59
- 出典データセット
- uspto-grants-2012_05
- 特許番号
- US08183366B2
反応ノート
読み込み中…