Lithium Hydroxide → 4-m-tolyloxy-1H-indole-2-carboxylic acid
反応式
C([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[C:12]([O:15][C:16]1[CH:17]=[C:18]([CH3:22])[CH:19]=[CH:20][CH:21]=1)[CH:11]=[CH:10][CH:9]=2)=[O:5])C.[Li+].[OH-]>CO.O>[C:18]1([CH3:22])[CH:19]=[CH:20][CH:21]=[C:16]([O:15][C:12]2[CH:11]=[CH:10][CH:9]=[C:8]3[C:13]=2[CH:14]=[C:6]([C:4]([OH:5])=[O:3])[NH:7]3)[CH:17]=1参加物
5
実験手順
136 (520 mg, 1.761 mmol) is dissolved in 10 ml of methanol and treated with a solution of LiOH (84.3 mg, 3.52 mmol) in 5 ml of water. The mixture is stirred at room temperature for 18 hours. After evaporation, the crude product is acidified at 0° C. with 2M HCl and extracted with ethyl acetate. The organic layers are dried over sodium sulphate and evaporated.
後処理
- customAfter evaporation
- customis acidified at 0° C. with 2M HCl
- extractionextracted with ethyl acetate
- dry with materialThe organic layers are dried over sodium sulphate
- customevaporated
出典と根拠
- ORDレコード
- ord-34b3614450c14a8c943aa10640958b3f
- 出典データセット
- uspto-grants-2012_05
- 特許番号
- US08183366B2
反応ノート
読み込み中…