5-bromo-2-fluoro-N-methoxy-N-methylbenzamide → (5-Bromo-2-fluorophenyl)(cyclopropyl)methanone
反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:14])=[C:6]([CH:13]=1)[C:7](N(OC)C)=[O:8].[CH:15]1([Mg]Br)[CH2:17][CH2:16]1>O1CCCC1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:14])=[C:6]([C:7]([CH:15]2[CH2:17][CH2:16]2)=[O:8])[CH:13]=1参加物
4
実験手順
In an analogous manner to that described for the preparation of Building block C [a)], the reaction of 5-bromo-2-fluoro-N-methoxy-N-methyl-benzamide with cyclopropylmagnesium bromide in tetrahydrofuran yielded the title compound as a light yellow liquid; (HPLC 2.783 min 100%). Mass (calculated) C10H8BrFO [243.074]; (found) [M+H]+=243, [M+2-H]+=245.
後処理
- customIn an analogous manner to that described for the preparation of Building block C [a)],
出典と根拠
- ORDレコード
- ord-b8d362aeb98c4869875bf1f61a674324
- 出典データセット
- uspto-grants-2012_05
- 特許番号
- US08188079B2
反応ノート
読み込み中…