Sodium Hydroxide → 3,4-Xylyloxyacetic acid
反応式
C[O:2][C:3](=[O:14])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([CH3:12])=[C:8]([CH3:13])[CH:7]=1.[OH-].[Na+]>CO>[CH3:13][C:8]1[CH:7]=[C:6]([CH:11]=[CH:10][C:9]=1[CH3:12])[O:5][CH2:4][C:3]([OH:14])=[O:2]参加物
4
実験手順
A solution of (3,4-dimethyl-phenoxy)-acetic acid methyl ester (7.399 g; 38.099 mmol) in MeOH (100 ml) was treated with aq. 1N NaOH (57 ml; 1.5 eq.), and the resulting mixture was further stirred at rt for 30 min. MeOH was then removed under reduced pressure, water (100 ml) was added followed by aq. 1N HCl (75 ml). Filtration of the precipitated solid, and drying under HV afforded (3,4-dimethyl-phenoxy)-acetic acid as a colorless solid (6.070 g; 88%). LC-MS: tR=0.81 min.; [M+H]+: no ionisation.
後処理
- customMeOH was then removed under reduced pressure, water (100 ml)
- additionwas added
- filtrationFiltration of the precipitated solid
- customdrying under HV
出典と根拠
- ORDレコード
- ord-57cb984dd9894486ba8706a5b5c2169e
- 出典データセット
- uspto-grants-2012_05
- 特許番号
- US08188082B2
反応ノート
読み込み中…