HCID 178418361、化合物 → HCID 178501606、化合物

HRID 19300ノート

反応式

HRID 19300 の反応式
[CH3:1][O:2][C:3](=[O:22])/[C:4](/[NH:11]C(OCC1C=CC=CC=1)=O)=[CH:5]/[C@H:6]1[CH2:9][C@H:8]([CH3:10])[CH2:7]1.[H][H]>[Pd].CO>[CH3:1][O:2][C:3](=[O:22])[CH:4]([NH2:11])[CH2:5][C@H:6]1[CH2:7][C@H:8]([CH3:10])[CH2:9]1

参加物

5

反応物 2

HCID 178418361HCID 178418361、化合物HCID 178500468HCID 178500468、化合物

生成物 1

HCID 178501606HCID 178501606、化合物収率 87.3%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

In a Parr shaker bottle was placed (Z)-2-benzyloxycarbonylamino-3-(trans-3-methyl-cyclobutyl)-acrylic acid methyl ester (300 mg, 0.99 mmol), methanol (10 mL) and 10% palladium on activated carbon (60 mg). The mixture was placed on the Parr hydrogenator and charged with 40 psi hydrogen pressure and shaken for 1.5 h. After such time, the catalyst was filtered off through a plug of celite and the filterate concentrated in vacuo to afford 2-amino-3-(trans-3-methyl-cyclobutyl)-propionic acid methyl ester (148 mg, 87%) as a pale yellow oil.

後処理

  1. filtrationAfter such time, the catalyst was filtered off through a plug of celite
  2. concentrationthe filterate concentrated in vacuo

出典と根拠

ORDレコード
ord-93df58aa04ce436498a50dd4958b3876
出典データセット
uspto-grants-2010_06
特許番号
US07741327B2

反応ノート

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