(6-Chloro-4-(phenylamino)pyridin-3-yl)methanol → 6-Chloro-4-phenylamino-pyridine-3-carbaldehyde
反応式
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][OH:9])=[C:4]([NH:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:3]=1>C(Cl)Cl.O=[Mn]=O>[Cl:1][C:2]1[CH:3]=[C:4]([NH:10][C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:5]([CH:8]=[O:9])=[CH:6][N:7]=1参加物
4
実験手順
MnO2 (39 g, 448 mmol) was added to a solution of (6-chloro-4-phenylamino-pyridin-3-yl)-methanol (13 g, 56 mmol) in CH2Cl2 (100 ml) and the mixture was stirred at RT overnight. The solids was removed by filtration and the filtrate was concentrated to give 6-chloro-4-(phenylamino)nicotinaldehyde (11 g, 86% yield). 1H-NMR (400 MHz, DMSO-d6): δ 10.18 (s, 1H), 9.99 (s, 1 H), 8.62 (s, 1 H), 7.49-7.31 (m, 5 H), 6.80 (s, 1 H).
後処理
- customThe solids was removed by filtration
- concentrationthe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-ebf072c8500f416f8157b4968a82ffd2
- 出典データセット
- uspto-grants-2012_05
- 特許番号
- US08188113B2
反応ノート
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