HCID 178418361、化合物 → HCID 178501606、化合物

HRID 19304ノート

反応式

HRID 19304 の反応式
[CH3:1][O:2][C:3](=[O:22])/[C:4](/[NH:11]C(OCC1C=CC=CC=1)=O)=[CH:5]/[C@H:6]1[CH2:9][C@@H:8]([CH3:10])[CH2:7]1.[H][H]>[Pd].CO>[CH3:1][O:2][C:3](=[O:22])[CH:4]([NH2:11])[CH2:5][C@H:6]1[CH2:7][C@H:8]([CH3:10])[CH2:9]1

参加物

5

反応物 2

HCID 178418361HCID 178418361、化合物HCID 178500467HCID 178500467、化合物

生成物 1

HCID 178501606HCID 178501606、化合物収率 86%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of (Z)-2-benzyloxycarbonylamino-3-(cis-3-methyl-cyclobutyl)-acrylic acid methyl ester (prepared in Example 214, 275 mg, 0.91 mmol), methanol (10 mL) and 10% palladium on activated carbon (50 mg) was placed in a Parr shaker bottle. It was then placed on the Parr hydrogenator apparatus and charged with hydrogen to 40 psi and shaken for 1 h. After such time, the catalyst was filtered through a plug of celite and the filterate was concentrated in vacuo to afford 2-amino-3-(trans-3-methyl-cyclobutyl)-propionic acid methyl ester (134 mg, 86%) as a pale yellow oil.

後処理

  1. filtrationAfter such time, the catalyst was filtered through a plug of celite
  2. concentrationthe filterate was concentrated in vacuo

出典と根拠

ORDレコード
ord-d6e3a768c45d4082a29ecb4dd6fc23be
出典データセット
uspto-grants-2010_06
特許番号
US07741327B2

反応ノート

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