Water → HCID 58009151、化合物

HRID 1930401ノート

反応式

HRID 1930401 の反応式
Cl[C:2]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:6][N:5]=[C:4]([Cl:13])[CH:3]=1.[CH2:14]([NH2:16])[CH3:15].O>CC#N>[Cl:13][C:4]1[CH:3]=[C:2]([NH:16][CH2:14][CH3:15])[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:6][N:5]=1

参加物

5

反応物 3

HCID 962WaterHCID 6341EthylamineHCID 600045Ethyl 4,6-dichloropyridine-3-carboxylate

生成物 1

HCID 58009151HCID 58009151、化合物収率 91%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To a solution of ethyl 4,6-dichloronicotinate (4.4 g, 20 mmol) in CH3CN (50 mL) was added dropwise a solution of ethylamine in water (65%, 2.7 g, 39 mmol) at 0° C., then the resulting mixture was stirred at RT overnight. The reaction was concentrated and the residue was washed with water to give ethyl 6-chloro-4-(ethylamino)nicotinate (3.9 g, 91% yield). 1H NMR (400 MHz, DMSO-d6): δ 8.51 (s, 1 H), 8.08 (s, 1 H), 6.53 (m, 1 H), 4.19 (q, J=7.2 Hz, 2H), 2.78 (q, J=7.2 Hz, 2 H), 1.28 (t, J=7.2 Hz, 3 H), 1.13 (t, J=7.2 Hz, 3 H); MS (ESI) m/z: 229.1[M+H]+.

後処理

  1. concentrationThe reaction was concentrated
  2. washthe residue was washed with water

出典と根拠

ORDレコード
ord-a600b71f35e740ac8e51a6d9c6be6505
出典データセット
uspto-grants-2012_05
特許番号
US08188113B2

反応ノート

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