化工社化工社 化学情報印刷レポート · 研究参考用
1,1'-Carbonyldiimidazole → 1-(1H-imidazol-1-yl)-3-(tetrahydrofuran-2-yl)propan-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 反応物 | 3-(Oxolan-2-yl)propanoic acid | HCID 263161 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-(1H-imidazol-1-yl)-3-(tetrahydrofuran-2-yl)propan-1-one | HCID 59333745 | 100.1% |
反応手順
Di-(1H-imidazol-1-yl)methanone (0.554 g, 3.42 mmol) was added in small portions to a stirred solution of 3-(tetrahydrofuran-2-yl)propanoic acid (0.469 g, 3.25 mmol) in dichloromethane (3 mL) at room temperature under argon. The reaction mixture is stirred at room temperature for 2 hours. The mixture was washed twice with water, dried over MgSO4 and concentrated resulting a quantitative yield of 1-(1H-imidazol-1-yl)-3-(tetrahydrofuran-2-yl)propan-1-one (632 mg, 100%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08188101B2 |
| 出典データセット | uspto-grants-2012_05 |
| ORD ID | ord-2cb04fbc9ad746529d70a437f4cdea17 |
| 出典メモ | uspto-grants-2012_05 |