Thionyl Chloride → 2-(Cyclopentyloxy)acetyl chloride

HRID 1930717ノート

反応式

HRID 1930717 の反応式
[CH:1]1([O:6][CH2:7][C:8]([OH:10])=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.S(Cl)([Cl:13])=O>>[CH:1]1([O:6][CH2:7][C:8]([Cl:13])=[O:10])[CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 13355021(Cyclopentyloxy)acetic acid

生成物 1

HCID 866419172-(Cyclopentyloxy)acetyl chloride収率 100%

実験手順

2-(Cyclopentyloxy)acetic acid (476mg, 3.3 mmol) was heated to reflux in thionyl chloride (0.365 ml, 5.00 mmol). After 30 min the excess of thionyl chloride was evaporated to afford (2-(cyclopentyloxy)acetyl chloride (3.3 mmol) that was used directly in the next step.

後処理

  1. customAfter 30 min the excess of thionyl chloride was evaporated

出典と根拠

ORDレコード
ord-cba6a54ec743409aa8f5010466e38fb3
出典データセット
uspto-grants-2012_05
特許番号
US08188101B2

反応ノート

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