Thionyl Chloride → HCID 59333778、化合物

HRID 1930720ノート

反応式

HRID 1930720 の反応式
[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][CH2:8][C:9]([OH:11])=O.S(Cl)(Cl)=O.O=C1CCCN1CCC(Cl)=O.[O:27]1[CH2:32][CH2:31][C:30](=[O:33])[CH2:29][CH2:28]1>>[O:11]=[C:9]([CH:29]1[C:30](=[O:33])[CH2:31][CH2:32][O:27][CH2:28]1)[CH2:8][CH2:7][N:3]1[CH2:4][CH2:5][CH2:6][C:2]1=[O:1]

参加物

5

反応物 4

HCID 24386Thionyl ChlorideHCID 121599Tetrahydro-4H-pyran-4-oneHCID 31466882-Oxo-1-pyrrolidinepropanoic acidHCID 12843799HCID 12843799、化合物2 回

生成物 1

HCID 59333778HCID 59333778、化合物収率 25.6%

実験手順

3-(2-Oxopyrrolidin-1-yl)propanoic acid (519 mg, 3.3 mmol) was heated to reflux in thionyl chloride (0.365 ml, 5.00 mmol) for 30 min. The excess of thionyl chloride was evaporated and the product, (3-(2-oxopyrrolidin-1-yl)propanoyl chloride (3.3 mmol)) used as such in the next step. 1-(3-oxo-3-(4-oxotetrahydro-2H-pyran-3-yl)propyl)pyrrolidin-2-one (202 mg, 15%) was synthesised from dihydro-2H-pyran-4(3H)-one (0.462 ml, 5.00 mmol) and 3-(2-oxopyrrolidin-1-yl)propanoyl chloride (3.3 mmol) by the general procedure for the preparation of diketones.

後処理

  1. customThe excess of thionyl chloride was evaporated

出典と根拠

ORDレコード
ord-e4ca1242ece74fbbbd97f1b2c853f409
出典データセット
uspto-grants-2012_05
特許番号
US08188101B2

反応ノート

読み込み中…