Sodium Hydroxide → HCID 57753316、化合物
反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[N+:11]([O-])=O)[C:7](=[O:14])[NH:6][C:5]2=[O:15].[Sn](Cl)Cl.[OH-].[Na+]>Cl>[NH2:11][C:10]1[CH:9]=[C:8]2[C:4](=[CH:3][C:2]=1[F:1])[C:5](=[O:15])[NH:6][C:7]2=[O:14]参加物
5
反応条件
- 温度
- 60 °C
実験手順
To a suspension of 99.9 mmol 5-fluoro-6-nitro-isoindole-1,3-dione in 400 ml concentrated hydrochloric acid was added 350 mmol tin(II) chloride dehydrate and the resulting mixture was heated at 60° C. for 2 h. The reaction mixture was then poured onto ice-water and then 28% aq sodium hydroxide was added with stirring until a suspension was formed. The crystals were collected by filtration and dried in vacuo to afford the title compound as a yellow solid (80% yield). MS (m/e): 179.1 ([M−H]−, 100%).
後処理
- additionThe reaction mixture was then poured onto ice-water
- customwas formed
- filtrationThe crystals were collected by filtration
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-73624b061f6b48f89f73808910940ae3
- 出典データセット
- uspto-grants-2012_05
- 特許番号
- US08188139B2
反応ノート
読み込み中…