Ethopabate → 4-(2,6-Dimethylimidazo[4,5-b]pyridin-3-yl)-2-ethoxybenzoic acid methyl ester

HRID 1931286

反応式

HRID 1931286 の反応式
Cl[C:2]1[C:7]([N+:8]([O-])=O)=[CH:6][C:5]([CH3:11])=[CH:4][N:3]=1.[CH3:12][O:13][C:14](=[O:28])[C:15]1[CH:20]=[CH:19][C:18]([NH:21][C:22](=O)[CH3:23])=[CH:17][C:16]=1[O:25][CH2:26][CH3:27]>>[CH3:12][O:13][C:14](=[O:28])[C:15]1[CH:20]=[CH:19][C:18]([N:21]2[C:2]3=[N:3][CH:4]=[C:5]([CH3:11])[CH:6]=[C:7]3[N:8]=[C:22]2[CH3:23])=[CH:17][C:16]=1[O:25][CH2:26][CH3:27]

参加物

3

反応物 2

HCID 6034EthopabateHCID 8183002-Chloro-5-methyl-3-nitropyridine

生成物 1

HCID 248215974-(2,6-Dimethylimidazo[4,5-b]pyridin-3-yl)-2-ethoxybenzoic acid methyl ester収率 84%

実験手順

Method B applied to 2-chloro-5-methyl-3-nitropyridine (86 mg, 0.5 mmol) and 4-acetylamino-2-ethoxybenzoic acid methyl ester (142 mg, 0.6 mmol) afforded the title compound as viscous oil (136 mg, 84%). 1H NMR (DMSO) δ 1.34 (t, J=6.9Hz, 3H), 2.46 (s, 3H), 2.61 (s, 3H), 3.82 (s, 3H), 4.12 (q, J=6.9Hz, 2H), 7.22 (d, J=8.0Hz, 1H), 7.50 (s, 1H), 7.83 (d, J=8.0Hz, 1H), 7.98 (s, 1H), 8.21 (s, 1H).

出典と根拠

ORDレコード
ord-8f4f262bee3e4fc7bce06abdca091ac4
出典データセット
uspto-grants-2012_05
特許番号
US08188282B2

関連ノート

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